A catechol-modified quaternized chitosan/PEG hydrogel for diabetic wound healing: synergistic effects of TGF-β3 delivery, angiogenesis, and antibacterial activity
The BP-QS/TGF-β3 hydrogel synergizes potent antibacterial action with sustained TGF-β3 delivery to disrupt the vicious cycle of biofilm infection and healing failure. This integrated, multidisciplinary strategy effectively targets the core pathology of diabetic wounds, offering a promising therapeutic platform for managing biofilm-infected chronic wounds.
Authors
- Huidong Chen (ORCID: https://orcid.org/0000-0001-7676-6350)
- Yiren Zhu (ORCID: https://orcid.org/0000-0002-8080-8338)
- Xueyi He
- Jiawei Yang (ORCID: https://orcid.org/0009-0006-7430-8042)
- Chenggang Huang (ORCID: https://orcid.org/0000-0001-9209-7484)
- Lei Zhu (ORCID: https://orcid.org/0000-0003-1685-7968)
- Zhengchao Zhang (ORCID: https://orcid.org/0000-0003-3291-2947)
- Xiu Yang (ORCID: https://orcid.org/0000-0003-4751-2751)
- Yang Lu (ORCID: https://orcid.org/0009-0000-8100-5257)
- Jiayu He (ORCID: https://orcid.org/0009-0007-6419-0690)
- Wubing He (ORCID: https://orcid.org/0009-0002-5187-6339)
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3389/fcimb.2025.1717082
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province