Long-term low-dose aspirin promotes laser-induced choroidal neovascularization through suppressing TSP-1 expression
Low-dose long-term aspirin use promoted the severity of laser-induced CNV by down-regulating TSP-1. Lower serum levels of TSP-1 may be a risk factor for nAMD. The long-term ocular safety of aspirin should be validated in prospective cohorts.
Authors
- Jiawu Zhao (ORCID: https://orcid.org/0009-0001-7199-0270)
- Rosana Peñalva
- Usha Chakravarthy (ORCID: https://orcid.org/0000-0002-2606-3734)
- Christophe Roubeix (ORCID: https://orcid.org/0000-0002-0144-0556)
- Chang Luo
- Florian Sennlaub (ORCID: https://orcid.org/0000-0003-4412-1341)
- Caijiao Yi
- Heping Xu (ORCID: https://orcid.org/0000-0003-4000-931X)
- Mei Chen (ORCID: https://orcid.org/0000-0001-5661-1386)
- Jian Liu (ORCID: https://orcid.org/0000-0001-5548-1858)
- Qichang Wang (ORCID: https://orcid.org/0000-0003-1231-2821)
- Judith Lechner (ORCID: https://orcid.org/0000-0002-3315-5282)
- Nan Yang (ORCID: https://orcid.org/0000-0002-6052-5728)
Institutions
- Queen's University Belfast (GB)
- Centre National de la Recherche Scientifique (FR)
- Institut de la Vision (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- He Eye Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3389/fncel.2025.1716229
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council
- Agencia Estatal de Investigación