In(OTf) <sub>3</sub> -Catalyzed [3 + 2] Cycloaddition Reactions of Donor–Acceptor Cyclopropanes with Thioamides
An In(OTf)<sub>3</sub>-catalyzed [3 + 2] cycloaddition reaction between donor-acceptor cyclopropanes enabled by a single keto acceptor (cyclopropyl ketones) and thioamides has been developed. The broad substrate scope has been demonstrated by synthesizing a series of new highly functionalized dihydrothiophenes with up to a 95% isolated yield. In addition, the protocol can be applied to the double [3 + 2] cycloaddition reactions of bicyclopropanes with thioamide.
Authors
- Yue Lu (ORCID: https://orcid.org/0000-0001-9800-3792)
- Yan Jiang (ORCID: https://orcid.org/0000-0003-3111-4097)
- Wenzhi Zhao
- Chen-Ying Zhai
Institutions
- China West Normal University (CN)
- Division of Materials Science and Engineering (AU)
- Green Chemistry (PL)
- Chemical Synthesis Lab (SG)
- Sichuan University of Science and Engineering (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1021/acs.joc.5c01959
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00