Delayed Disease Onset Report in <scp>UK</scp> Biobank: Implications for Prodromal Studies in Parkinson's Disease
Substantial delays in PD documentation may misclassify already diagnosed individuals as prodromal. This introduces significant bias into studies of early disease markers and distorts the timing between risk factors and clinical onset. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Sheida Zolfaghari (ORCID: https://orcid.org/0000-0002-2269-7473)
- Tim Wilkinson (ORCID: https://orcid.org/0000-0001-8952-0982)
- Filip Morys (ORCID: https://orcid.org/0000-0001-8996-2676)
- Daniel Belete (ORCID: https://orcid.org/0000-0002-0026-962X)
- Kathryn Bush (ORCID: https://orcid.org/0000-0002-4422-4749)
- Ronald B. Postuma (ORCID: https://orcid.org/0000-0002-6468-4734)
- Aline Delva (ORCID: https://orcid.org/0000-0001-8497-2314)
- Alastair John Noyce (ORCID: https://orcid.org/0000-0003-3027-5497)
- Sheena Waters (ORCID: https://orcid.org/0000-0001-7241-2272)
- Kristiina Rannikmäe (ORCID: https://orcid.org/0000-0002-2384-7568)
- Sarah Bouhadoun (ORCID: https://orcid.org/0009-0000-5500-3151)
- Amélie Pelletier (ORCID: https://orcid.org/0009-0001-5930-9796)
- Andrew Vo
- Trycia Kouchache (ORCID: https://orcid.org/0009-0009-6970-806X)
- Mirja Kuhlencord
- Alain Dagher
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Queen Mary University of London (GB)
- University of Toronto (CA)
- Johannes Gutenberg University Mainz (DE)
- McGill University Health Centre (CA)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Hôpital du Sacré-Cœur de Montréal (CA)
- The Queen's Medical Research Institute (GB)
- McGill University (CA)
- Newcastle University (GB)
- University of Edinburgh (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1002/mds.70147
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78