Cycloastragenol Regulates Mitochondrial Homeostasis–Mediated Renal Tubular Injury to Ameliorate Diabetic Kidney Disease by Directly Targeting <scp>ERK</scp> to Modulate <scp>TFEB</scp>
CAG ameliorated renal tubule damage in DKD by regulating mitochondrial quality though targeting ERK to regulate TFEB. This research advances drug development and proposes lifestyle interventions (e.g., dietary supplements).
Authors
- Gai Gao
- Zhenqiang Zhang (ORCID: https://orcid.org/0000-0002-1736-1289)
- Zhishen Xie (ORCID: https://orcid.org/0000-0002-0008-9637)
- Jiangyan Xu (ORCID: https://orcid.org/0000-0002-8723-1463)
- Yanrao Wu
- Rong Liu (ORCID: https://orcid.org/0000-0002-4484-5203)
- Xiaowei Zhang (ORCID: https://orcid.org/0000-0002-2016-4032)
- Pan Wang (ORCID: https://orcid.org/0000-0002-9779-1878)
- Zhenzhen Wang (ORCID: https://orcid.org/0000-0003-4645-0958)
- Hui Wang (ORCID: https://orcid.org/0000-0003-2633-6015)
- Zhiwen Liu (ORCID: https://orcid.org/0000-0002-8794-173X)
- Shu-Yan Liu (ORCID: https://orcid.org/0000-0001-9345-0825)
Institutions
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Phytotherapy Research
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1002/ptr.70136
- Citations
- 1
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.43