Understanding Cardiovascular Events With <scp>JAK</scp> Inhibitors: Similarities and Differences of the Vascular Effects Between Different <scp>JAK</scp> Inhibitors on Endothelial Cells Exposed to Inflammatory Cytokines

All JAKi reduced EC inflammation but most JAKi could not prevent the up-regulation of adhesion molecules or the increase in procoagulant and the decrease in anticoagulant factors triggered by proinflammatory cytokines. Peficitinib and fedratinib exhibited cytotoxic effects causing EC apoptosis.