Mapping the brain cell–specific regulatory architecture of migraine: a single-cell causal framework nominating inhibitory-neuronal BTBD16 and astrocytic RIMS1 as therapeutic targets
Cell-type-specific MR sharpens migraine mechanisms beyond bulk tissue and prioritizes inhibitory-neuronal BTBD16 (protective) and astrocytic RIMS1 (risk-increasing) for mechanistic validation and therapeutic exploration.
Authors
- Chunmiao Jiang (ORCID: https://orcid.org/0000-0002-9571-0958)
- Cheng Wang (ORCID: https://orcid.org/0000-0002-1834-2119)
- Qiuhan Xu
- Juan Jin
- Jun‐Jie Fang (ORCID: https://orcid.org/0000-0001-7317-6566)
- Yajing Huang (ORCID: https://orcid.org/0000-0001-7876-165X)
Institutions
- Tongji University (CN)
- Wenzhou Medical University (CN)
- The Fourth People's Hospital (CN)
- Ningbo No. 2 Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Tongji Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s10194-025-02241-7
- Citations
- 1
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47