Proteomic ratio reveals subtype-specific genetic mechanisms and therapeutic targets in osteoarthritis
This study provides new insights into the genetic and molecular mechanisms of OA subtypes, highlighting potential therapeutic targets. The integration of protein ratio GWAS with network MR offers a comprehensive approach to understanding the complex pathogenesis of OA and emphasizes the need for subtype-specific therapeutic strategies.
Authors
- Longteng Liao
- Xia Yang (ORCID: https://orcid.org/0000-0002-3971-038X)
- Qian Zhang (ORCID: https://orcid.org/0000-0002-6415-4549)
- Yuehua Wang (ORCID: https://orcid.org/0000-0002-8470-742X)
- Hui Che (ORCID: https://orcid.org/0000-0002-2763-4068)
Institutions
- Shangrao Normal University (CN)
- Suzhou Municipal Hospital (CN)
Publication Details
- Journal
- Clinical Proteomics
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12014-025-09573-1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00