Signal regulating proteins (SIRPs) participate in sarcoidosis granuloma formation by promoting immune cell aggregation
SIRPα is robustly expressed in monocyte/macrophage lineages within human sarcoidosis tissues, and inhibition of SIRPs (ELA026) suppresses sarcoidosis granuloma formation by preventing macrophage adhesion/aggregation.
Authors
- Paul J. Feustel (ORCID: https://orcid.org/0000-0002-6963-4349)
- Sandip Panicker (ORCID: https://orcid.org/0000-0001-7901-2730)
- Elliott D. Crouser (ORCID: https://orcid.org/0000-0003-3197-6746)
- Soe Htet Arker (ORCID: https://orcid.org/0000-0002-9433-0486)
- Llewellyn Foulke
- Marc A. Judson (ORCID: https://orcid.org/0000-0002-4663-7985)
- M Julián (ORCID: https://orcid.org/0009-0007-8891-5422)
- Graham C. Parry (ORCID: https://orcid.org/0000-0002-3009-4947)
- Sabahattin Bicer
Institutions
- The Ohio State University Wexner Medical Center (US)
- Rapt Therapeutics (United States) (US)
- The Ohio State University (US)
- Albany Medical Center Hospital (US)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12931-025-03432-1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00