CircRNF10 sequestrates β-catenin by a dual regulatory circuit of direct degradation and a miR-1275/DKK3-mediated inhibition in driver gene- negative lung adenocarcinoma
Collectively, our findings highlight circRNF10 as a tumor suppressor in driver gene-negative LUAD and suggest that restoring circRNF10 expression represents a promising therapeutic approach for this refractory subtype.
Authors
- Honglei Chen (ORCID: https://orcid.org/0000-0003-3446-7779)
- Lihong Wei
- Peng Wu (ORCID: https://orcid.org/0000-0003-1562-699X)
- Fu‐Min Fang (ORCID: https://orcid.org/0000-0003-0165-771X)
- Lihong Bai
- Sicheng Chen (ORCID: https://orcid.org/0000-0001-5613-5105)
- Zunfu Ke (ORCID: https://orcid.org/0000-0002-6251-7246)
- Xiaohua Situ
- Zhiyu Liu (ORCID: https://orcid.org/0000-0002-1678-5960)
- Xiaoxuan Zhang (ORCID: https://orcid.org/0000-0002-0844-5712)
- Xin Wei Wang (ORCID: https://orcid.org/0000-0001-9735-606X)
- Xu Liao (ORCID: https://orcid.org/0009-0001-4945-9184)
- Kejing Tang (ORCID: https://orcid.org/0000-0002-5454-4666)
Institutions
- Sun Yat-sen University (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s12943-025-02530-4
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00