<scp>SPP1</scp> / <scp>OPN</scp> Alleviates Post‐Intracerebral Hemorrhage Depression and Cognitive Impairment via <scp>Nrf2</scp> / <scp>BDNF</scp> Signaling Activation in Mice
Our study is the first to demonstrate the critical role of SPP1 signaling in post-ICH depression through modulation of the Nrf2/BDNF pathway, providing novel therapeutic targets for clinical management of this debilitating neuropsychiatric sequela.
Authors
- Xu‐Qi Zhang
- Shaojun Du (ORCID: https://orcid.org/0000-0001-9227-4153)
- Yangyang Gao (ORCID: https://orcid.org/0000-0002-2246-9155)
- Zhanglei Mu (ORCID: https://orcid.org/0000-0003-3470-608X)
- Xudong Zhao (ORCID: https://orcid.org/0000-0002-1864-4686)
- Zhenyu Tao (ORCID: https://orcid.org/0000-0001-9892-9392)
- Pengpeng Li (ORCID: https://orcid.org/0000-0001-6653-7183)
Institutions
- Jiangnan University (CN)
- Nantong University (CN)
- Wuxi No.2 People's Hospital (CN)
- Ningxia Medical University (CN)
- Wuxi Institute of Technology (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cns.70680
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China