A novel method for the mechanochemical synthesis of unsymmetrical disulfides using phosphorodithioic acid derivatives

In this study, we report the efficient synthesis of unsymmetrical disulfides using a mechanochemical ball-milling approach. This research successfully yielded alkyl-alkyl, alkyl-aryl, and aryl-aryl unsymmetrical disulfides without any detectable formation of symmetrical products. Additionally, we eliminated the use of solvent in the reaction mixture and replaced triethylamine with the more environmentally friendly cesium carbonate as a base. These results represent a significant advancement in the modern synthesis of disulfides, which have applications in pharmacology.