Association between left ventricle diastolic dysfunction and circadian blood pressure pattern in arterial hypertension

To assess the relationship between left ventricular diastolic dysfunction (LVDD) and circadian blood pressure (BP) pattern in arterial hypertension (AH). A total of 96 patients with AH of I-II grades were examined. Transthoracic echocardiography was performed using a high-end ultrasound device GE Vivid 7 Pro (USA). 24-hour Ambulatory BP Monitoring was carried out using a Microlife Watch BP 03 device on the non-dominant arm. Statistical analysis of the obtained results was carried out using the Statistica 10.0 application package. After echocardiography all patients were divided into two groups. The first group is patients with AH and LVDD (n = 37), second group is patients with AH without LVDD (n = 59). The dipper pattern of systolic BP (SBP) was significantly more common in patients in the second group (p = 0.014). The non-dipper pattern of diastolic BP (DBP) was significantly more common in patients of group 1 (p = 0.047). The odds ratio of LVDD developing in patients with AH and a non-dipper pattern of SBP and DBP was 2.907 (95% confidence interval (CI) 1.233–6.852) and 3.329 (95% CI 1.346–8.234), respectively. A non-dipper pattern of SBP and DBP was significantly associated with LVDD and may be a therapeutic target for preservation of the diastolic function.