A comparative cohort study of epilepsy in children in Greenland and Denmark

Few studies on epilepsy in Greenlandic children exist, and the results are inconsistent. The objective of this study was to estimate the burden of epilepsy in children in Greenland and Denmark and secondly to identify demographic risk factors. Third, the risk of epilepsy after febrile seizures should be estimated. A register-based cohort study of all children in Greenland and Denmark aged 0-15 years from 1987 to 2014 was conducted. Using the Greenlandic and Danish National Patient Register, cases were identified and coupled to demographics through the Civil Registration System. The outcomes were incidence rates (IR) per 100,000 person-years (PY) and hazard ratios (HR).The study showed an epilepsy IR of 150/100,000 PY (139-162) in Greenland and 110/100,000PY (108-111) in Denmark and an HR of 1.34. The IRs were very high in the first years of life. A significantly higher HR was found for male sex, Inuit ethnicity in Greenland and habitation in Greenland outside of the capital. The risk of epilepsy after the diagnosis of febrile seizures was almost doubled in Greenland compared with Denmark.