Emodin inhibits colon cancer tumor growth by suppressing tumor cell glycolysis through inhibition of NAT10-mediated PGK1 ac4C modification
In conclusion, we demonstrated that emodin inhibited tumor growth of colon cancer by suppressing glycolysis in tumor cells through inhibiting NAT10-mediated ac4C modification of PGK1, indicating that emodin is an effective medicine for treatment of colon cancer.
Authors
- Weimin Zhang (ORCID: https://orcid.org/0000-0002-3348-9813)
- Zhuo Lv
- Zhuo-Qun Wei
Institutions
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3389/fonc.2025.1575391
- Citations
- 1
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 1.75