Monocyte–red blood cell crosstalk supports clearance and heme metabolism in sickle cell anemia
Circulating monocytes from SCA patients undergo phenotypic and functional reprogramming upon interaction with sickled RBCs, acquiring features reminiscent of erythroblastic island macrophages. These findings highlight a previously underappreciated role for monocytes in RBC clearance, heme metabolism, and iron recycling in SCA, with potential implications for inflammation and disease progression.
Authors
- Daniela Pinheiro Leonardo
- Renata Sesti‐Costa (ORCID: https://orcid.org/0000-0002-7098-2850)
- Carolina Lanaro (ORCID: https://orcid.org/0000-0003-3095-8036)
- Marina Dorigatti Borges (ORCID: https://orcid.org/0000-0002-0327-6083)
- Fernando Ferreira Costa (ORCID: https://orcid.org/0000-0002-4632-572X)
- Dulcinéia Martins de Albuquerque (ORCID: https://orcid.org/0000-0003-4451-3716)
- Izabela Felice Paes
- Sara T.O. Saad
- Matheus Ajeje de Souza
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1699306
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico