Pig regulatory macrophages as a donor-derived immune modulators in xenotransplantation
These findings highlight the cross-species immunosuppressive activity and coagulation-regulatory capacity, suggesting the potential relevance to xenograft injury. pMregs may therefore serve as a promising candidate for further investigations as a donor-derived immunoregulatory cell type to complement genetically engineered pig grafts.
Authors
- Joohyun Shim (ORCID: https://orcid.org/0000-0002-3021-5008)
- Ik Jin Yun (ORCID: https://orcid.org/0000-0003-4013-6714)
- Thi Xoan Hoang (ORCID: https://orcid.org/0000-0003-0401-5843)
- Phuoc-Vinh Nguyen (ORCID: https://orcid.org/0000-0002-7421-1623)
- Jonghyeok Jung
- Nhat Minh Dang
- Jeong Ho Hwang (ORCID: https://orcid.org/0000-0002-4763-8373)
- Jae‐Young Kim (ORCID: https://orcid.org/0000-0002-9423-438X)
- Phu Chi Vu
Institutions
- Gachon University (KR)
- Konkuk University (KR)
- Trường ĐH Nguyễn Tất Thành (VN)
- Konkuk University Medical Center (KR)
- Korea Institute of Toxicology (KR)
- Komipharm International (South Korea) (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1718937
- Citations
- 1
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Institute of Civil-Military Technology Cooperation
- Defense Acquisition Program Administration