Association Study on Multi‐Timepoint <scp>DNA</scp> Methylation Levels of Serotonin Transporter Gene and Adolescent Psychological‐Behavioral Development
DNA methylation levels in the SLC6A4 could potentially serve as epigenetic signatures for male adolescents exhibiting externalizing behavioral problems. To our knowledge, this is the first study to track SLC6A4 methylation at three developmental time points across early to mid-adolescence. Further epigenetic research is warranted to understand the role of environmental and genetic factors in the manifestation of adolescent behavioral problems.
Authors
- Naohiro Okada (ORCID: https://orcid.org/0000-0002-8338-2758)
- Kiyoto Kasai
- Syudo Yamasaki (ORCID: https://orcid.org/0000-0002-9016-6404)
- Daiki Nagaoka (ORCID: https://orcid.org/0000-0001-6054-3363)
- Kazuya Iwamoto (ORCID: https://orcid.org/0000-0002-1780-692X)
- Shuntaro Ando (ORCID: https://orcid.org/0000-0003-1595-693X)
- Yasuko Yanagida (ORCID: https://orcid.org/0000-0002-7882-3651)
- Shinsuke Koike (ORCID: https://orcid.org/0000-0002-3375-236X)
- Yutaka Nakachi (ORCID: https://orcid.org/0000-0003-1964-2495)
- Tempei Ikegame (ORCID: https://orcid.org/0009-0003-4436-3962)
- Emi Kiyota
- Miki Bundo (ORCID: https://orcid.org/0000-0002-5786-0509)
- Atsushi Nishida (ORCID: https://orcid.org/0000-0001-6451-7699)
Institutions
- Tokyo Metropolitan Institute of Medical Science (JP)
- RIKEN Center for Advanced Intelligence Project (JP)
- The University of Tokyo (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Neuropsychopharmacology Reports
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/npr2.70081
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- Research Institute of Science and Technology for Society
- Moonshot Research and Development Program