C2C12‐Derived ApoVs Promote Skeletal Muscle Development and Ameliorate Age‐Related Muscle Loss Through Igf1r/PI3K/AKT/mTOR Pathway
In summary, this study demonstrates the generation of apoVs during myogenic differentiation. The apoVs derived from skeletal muscle cells promote skeletal muscle cell differentiation and delay age-related muscle loss. These results provide a theoretical basis for elucidating the mechanism of skeletal muscle development and treating skeletal muscle-related diseases.
Authors
- Wenbin Bao (ORCID: https://orcid.org/0000-0001-5486-2253)
- Yi Liu (ORCID: https://orcid.org/0000-0003-2990-5738)
- Aiwen Jiang
- Shenglong Wu (ORCID: https://orcid.org/0000-0003-3876-9483)
- Haifei Wang (ORCID: https://orcid.org/0000-0003-2424-9743)
- Luyao Wang (ORCID: https://orcid.org/0000-0002-5274-7857)
Institutions
- Yangzhou University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jcsm.70159
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00