Base-controlled divergent synthesis of cyclopropyl aryl methanones from homopropargylic alcohols with DMTST
A method for synthesizing cyclopropyl aryl methanones from homopropargylic alcohols using dimethyl(methylthio)sulfonium trifluoromethanesulfonate has been developed. The reaction selectivity, governing the formation of cyclopropane or methylthio-cyclopropane architectures, is controlled by the choice of base. This reaction is initiated by the hydroxyl group and proceeds <i>via</i> intramolecular cyclization.
Authors
- Xiao‐Ming Ren (ORCID: https://orcid.org/0000-0003-0848-6503)
- Zhihua Wang (ORCID: https://orcid.org/0000-0001-8976-3212)
- Guojun Yu (ORCID: https://orcid.org/0000-0002-8599-9743)
- Rulong Yan (ORCID: https://orcid.org/0000-0002-0450-3065)
- Peihua Liu (ORCID: https://orcid.org/0000-0002-6890-276X)
- Hongliang Zhou (ORCID: https://orcid.org/0000-0001-6237-0873)
- Bing Hu
- Guangwei Hu
Institutions
- Jinchuan (China) (CN)
- Oil and Gas Center (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1039/d5cc05964j
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00