AXIN1 Polymorphisms Potentially Modulate Parkinson’s Disease Susceptibility: A Cross-Sectional Study in Northern Han Chinese and White Populations
Our findings support a gatekeeper role for AXIN1; its polymorphisms contribute to increased PD susceptibility and accelerated motor progression, yet may also trigger a compensatory presynaptic response, as evidenced by elevated CSF DOPA levels, to counteract neurodegeneration. Future studies should include larger sample sizes, more diverse ethnic populations, and protein-level investigations.
Authors
- Anmu Xie (ORCID: https://orcid.org/0000-0003-2591-467X)
- Binghui Hou (ORCID: https://orcid.org/0009-0009-1710-3579)
- Yaqing Li (ORCID: https://orcid.org/0000-0002-8858-4666)
- Zhen Xing Kong (ORCID: https://orcid.org/0000-0003-1961-1306)
- Qiqing He
- Chengqian Li (ORCID: https://orcid.org/0000-0002-3804-483X)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-5782-2174)
- Yuting Zhou (ORCID: https://orcid.org/0009-0000-8981-6724)
- Ran Yu (ORCID: https://orcid.org/0000-0002-8933-8774)
Institutions
- Qingdao University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Weifang People's Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Neurology and Therapy
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1007/s40120-025-00864-1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qingdao Postdoctoral Science Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation