Oestrogen-related receptor γ in sepsis-induced cardiomyopathy: role of cardiomyocyte subtype conversion
This study not only identifies cardiomyocyte subtype conversions as a key pathophysiological basis for SICM-induced cardiac dysfunction but also establishes ERRγ as the central regulatory mechanism governing these conversions. Activating ERRγ has the potential to ameliorate cardiac dysfunction in SICM. This work provides new insights into the pathophysiology of SICM, offering novel therapeutic strategies for its prevention and treatment.
Authors
- Yingnan Lyu (ORCID: https://orcid.org/0000-0002-6151-2419)
- Yingjia Li (ORCID: https://orcid.org/0000-0002-8885-2317)
- Xuya Kang (ORCID: https://orcid.org/0000-0002-6593-5347)
- Haibao Shang
- Xiaolu Shi (ORCID: https://orcid.org/0000-0002-5351-0894)
- Erdan Dong (ORCID: https://orcid.org/0009-0006-8737-5308)
- Wen Zheng (ORCID: https://orcid.org/0000-0002-2047-8496)
- Yusi Chen (ORCID: https://orcid.org/0000-0002-6077-6973)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-8322-467X)
- Yan Yao (ORCID: https://orcid.org/0000-0002-4003-4323)
- Wenjia Zhang (ORCID: https://orcid.org/0000-0002-9299-6137)
- Zeyuan Wang (ORCID: https://orcid.org/0000-0002-8384-2574)
- Shan Lu (ORCID: https://orcid.org/0000-0002-9756-7198)
- Yahan Liu (ORCID: https://orcid.org/0000-0002-5948-4615)
- Junxia Zhang (ORCID: https://orcid.org/0000-0001-7841-8675)
- Jing Su (ORCID: https://orcid.org/0000-0001-6797-1360)
- Jingli Yang (ORCID: https://orcid.org/0009-0007-1250-8345)
- Rui Ma (ORCID: https://orcid.org/0009-0003-5909-593X)
- Qian Liu (ORCID: https://orcid.org/0009-0008-1602-402X)
Institutions
- Qingdao University (CN)
- Capital Medical University (CN)
- Dalian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Beijing Anzhen Hospital (CN)
- Qingdao Municipal Hospital (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- China Academy of Chinese Medical Sciences (CN)
- Peking University Third Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1093/eurheartj/ehaf980
- Citations
- 2
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 2.78