miR-21-5p dysregulation is associated with gut microbiota dysbiosis and pro-oncogenic markers in primary sclerosing cholangitis with concomitant inflammatory bowel disease
This study found a link between miR-21-5p dysregulation and gut microbiota dysbiosis, colonic inflammation, and pro-oncogenic signaling in PSC-IBD patients. These findings highlight miR-21-5p as a potential modulator of disease progression and neoplastic risk.
Authors
- Catarina Gouveia (ORCID: https://orcid.org/0000-0002-4162-8473)
- Ricardo F. Crespo (ORCID: https://orcid.org/0000-0002-7555-5479)
- David Pires (ORCID: https://orcid.org/0000-0001-9602-1516)
- Pedro M. Rodrigues (ORCID: https://orcid.org/0000-0001-6193-7436)
- Vanda Marques (ORCID: https://orcid.org/0000-0003-3515-0781)
- Marília Cravo (ORCID: https://orcid.org/0000-0001-8309-4599)
- Joana Torres (ORCID: https://orcid.org/0000-0003-2895-5821)
- Susana Saraiva
- Jesús M. Bañales (ORCID: https://orcid.org/0000-0002-5224-2373)
- Cecília M. P. Rodrigues (ORCID: https://orcid.org/0000-0002-4829-754X)
- Luís Correia (ORCID: https://orcid.org/0000-0002-3443-5366)
- João Pereira da Silva
- André Anastácio Santos
- Ana Catarina Bravo (ORCID: https://orcid.org/0009-0008-1072-9053)
- Nicole Alesina
Institutions
- Ikerbasque (ES)
- University of Lisbon (PT)
- Universidade Católica Portuguesa (PT)
- Lusíada University of Lisbon (PT)
- Hospital da Luz (PT)
- Hospital Beatriz Ângelo (PT)
- Bioef - Fundación Vasca de Innovación e Investigación Sanitarias (ES)
- Hospital de Santa Maria (PT)
Publication Details
- Journal
- Experimental and Molecular Pathology
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1016/j.yexmp.2025.105013
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00