Telomere dynamics are influenced by sleep, sleep variability and circadian rhythms in older adults with or without alzheimer’s risk
This study suggests that poor sleep quality, sleep variability and circadian rhythm disturbances may accelerate cellular ageing through telomere shortening in older adults. Our results highlight the potential value of sleep interventions in mitigating biological ageing and reducing vulnerability to age-related diseases.
Authors
- Stéphane Rehel
- Gaël Chételat (ORCID: https://orcid.org/0000-0002-4889-7932)
- Vincent de La Sayette (ORCID: https://orcid.org/0000-0003-0663-092X)
- Géraldine Poisnel (ORCID: https://orcid.org/0000-0001-7943-1281)
- Florence Mézenge
- Brigitte Landeau
- P A Kaliman (ORCID: https://orcid.org/0009-0006-4299-4316)
- B Montagne
- Géraldine Rauchs
- Anne Chocat
- Asrar Lehodey
Institutions
- Universitat Oberta de Catalunya (ES)
- Inserm (FR)
- Normandie Université (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Cyceron (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s13195-025-01923-3
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00