Effects of Repeated Early-life Anesthesia Exposure on Visual System Development in Mice
These findings indicate that early repeated exposure to general anesthesia disrupts visual system maturation in mice and suggest that altered tissue-type plasminogen activator pathways may contribute to these effects, identifying tissue-type plasminogen activator as a potential marker of anesthesia-related neurodevelopmental vulnerability. Additional experimental work will be required to further support this association and clarify its underlying mechanisms.
Authors
- Denis Vivien (ORCID: https://orcid.org/0000-0002-7636-2185)
- Nicolas Poirel (ORCID: https://orcid.org/0000-0002-3972-2575)
- Jean‐Philippe Salaün (ORCID: https://orcid.org/0000-0002-2132-2231)
- Amandine Bonnet (ORCID: https://orcid.org/0000-0002-3485-8713)
- Gilles Orliaguet (ORCID: https://orcid.org/0000-0003-0930-2251)
- Shahad Albadri (ORCID: https://orcid.org/0000-0002-3243-7018)
- Célia Seillier (ORCID: https://orcid.org/0000-0002-5965-3626)
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Institut de la Vision (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Institut Necker Enfants Malades (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Normandie Université (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Cyceron (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1097/aln.0000000000005879
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00