Long-Lived Flexible Silicon Carbide Electronics for Cell Recording and <i>In Situ</i> Hyperthermia

This work presents a flexible, long-lived silicon carbide (SiC) electrode system for cell sensing and hyperthermia induction. Leveraging the superior chemical stability of SiC, mechanical robustness, and biocompatibility, the electrode demonstrates robust performance in both sensing and stimulation, while maintaining structural and functional integrity under physiological conditions. We assess the performance of the electrode system in the electrical measurements of breast cancer cells and its efficiency in eliminating the cells <i>via</i> <i>in situ</i> hyperthermia treatment at controlled temperatures. The longevity of our electrode system was examined <i>via</i> accelerated aging tests in phosphate-buffered saline (1× PBS) at elevated temperatures. Experimental results confirm the long-term stability of electrical signals, highly efficient heat generation and transfer, and sustained biocompatibility, indicating the potential for long-lived implanted bioelectronic interfaces.