Ginsenoside Re regulates PFKFB3-mediated glycolysis to inhibit endothelial cell migration to ameliorate atherosclerosis
Re may benefit AS mice by inhibiting EC glycolysis and migration through suppression of the PFKFB3-HIF-1α-VEGFA-VEGFR2 pathways. This work broadens the theoretical basis for the therapeutic use of Re in AS.
Authors
- Junyu Mou
- Min Wang (ORCID: https://orcid.org/0000-0001-7152-4838)
- Zhihui Wang (ORCID: https://orcid.org/0009-0008-0029-8413)
- Guibo Sun (ORCID: https://orcid.org/0000-0003-3202-6275)
- Siyuan Liu (ORCID: https://orcid.org/0009-0009-2138-5740)
- Wen Han (ORCID: https://orcid.org/0009-0007-2796-0748)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1016/j.jgr.2025.11.012
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00