High levels of nonblocking anti-interferon and anticytokine autoantibodies in individuals with mRNA vaccine–induced systemic allergic reactions
Our findings reveal a potential link between cytokine-targeting autoantibodies, especially anti-IFN-λ1, and systemic adverse responses to mRNA vaccination. These results suggest a role for immune dysregulation in individuals with hypersensitivity to mRNA vaccines and highlight the need for further investigation to improve vaccine safety and tolerance.
Authors
- Kari Christine Nadeau (ORCID: https://orcid.org/0000-0002-2146-2955)
- Muhammad Bilal Khalid (ORCID: https://orcid.org/0000-0002-4396-9984)
- Pamela A. Frischmeyer‐Guerrerio (ORCID: https://orcid.org/0000-0003-2259-5546)
- Allan Feng (ORCID: https://orcid.org/0000-0003-0122-7947)
- Shaurya Dhingra (ORCID: https://orcid.org/0000-0002-5327-7535)
- Müge Kalaycıoğlu (ORCID: https://orcid.org/0009-0006-5224-9926)
- Paul J. Utz
Institutions
- National Institutes of Health (US)
- Harvard University (US)
- University of Illinois Chicago (US)
- National Institute of Allergy and Infectious Diseases (US)
- Institute of Infection and Immunity (CA)
- Stanford University (US)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1016/j.jacig.2025.100622
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00