Stratification of brain-derived extracellular vesicles of Alzheimer’s disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles
This study highlights the significant contribution of AD-derived EVs to tau propagation and provides new insights into different roles of EV sub-populations in AD.
Authors
- Morvane Colin (ORCID: https://orcid.org/0000-0003-0611-4167)
- Claude‐Alain Maurage (ORCID: https://orcid.org/0000-0002-0229-6461)
- Balasubramaniam Namasivayam
- Romain Perbet
- Thomas Bouillet
- Luc Buée (ORCID: https://orcid.org/0000-0002-6261-4230)
- Danièle Mazur
- Élodie Leroux (ORCID: https://orcid.org/0000-0002-1216-4243)
- Soulaimane Aboulouard (ORCID: https://orcid.org/0000-0002-2045-4785)
- Christophe Lefebvre (ORCID: https://orcid.org/0000-0002-2690-373X)
- Anne Loyens (ORCID: https://orcid.org/0000-0002-5906-3204)
- Raphaëlle Caillierez (ORCID: https://orcid.org/0000-0002-6804-9586)
- Marie Oosterlynck
- Bertrand Accart
Institutions
- Inserm (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (FR)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-12-05
- DOI
- https://doi.org/10.1186/s40035-025-00519-z
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Infrastructures en Biologie Santé et Agronomie
- Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease
- Université de Lille
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique