Sex differences late after tetralogy of Fallot repair: a systematic review and meta-analysis

In view of significant long-term outcome differences in RV function and volume between males and females, we recommend a sex-specific threshold rather than a unisex threshold when it comes to consideration of the timing of re-intervention. More multi-centred studies are required to understand this better.Central message We have shown that there are long-term outcome differences between males and females. Therefore, we recommend sex-specific thresholds when it comes to consideration of timing for re-intervention. [Table: see text].