Age-related factors associated with preserved ratio impaired spirometry: The Tohoku medical Megabank project community-based cohort study
Our findings indicate that PRISm in younger adults is associated with hypothyroidism and underweight status, whereas in older adults, it is more closely related to constitutional and lifestyle-related factors. These results highlight the heterogeneity of PRISm and indicate that its pathophysiology and optimal management may vary by age group.
Authors
- Taku Obara (ORCID: https://orcid.org/0000-0002-3674-1674)
- Nobuo Fuse (ORCID: https://orcid.org/0000-0003-0237-4746)
- Tomoko Kobayashi (ORCID: https://orcid.org/0000-0002-2226-6702)
- Satoshi Nagaie (ORCID: https://orcid.org/0000-0002-8152-4556)
- Sayuri Tokioka (ORCID: https://orcid.org/0000-0003-0751-1674)
- Chikashi Iwasaki
- Rieko Hatanaka (ORCID: https://orcid.org/0000-0001-5729-4837)
- Eiichi N. Kodama (ORCID: https://orcid.org/0000-0002-6622-2752)
- Masato Takase (ORCID: https://orcid.org/0000-0001-7009-387X)
- Yohei Hamanaka (ORCID: https://orcid.org/0000-0003-4169-7767)
- Naoki Nakaya (ORCID: https://orcid.org/0000-0002-5344-8170)
- Soichi Ogishima (ORCID: https://orcid.org/0000-0001-8613-2562)
- Akira Koarai (ORCID: https://orcid.org/0000-0001-9147-4225)
- Mana Kogure (ORCID: https://orcid.org/0000-0003-2585-2405)
- Ippei Chiba (ORCID: https://orcid.org/0000-0003-1966-3595)
- Naoya Fujino (ORCID: https://orcid.org/0000-0003-3174-2632)
- Masatsugu Orui (ORCID: https://orcid.org/0000-0002-4871-8455)
- Shinichi Kuriyama (ORCID: https://orcid.org/0000-0003-2526-2974)
- Kumi Nakaya
- Hisatoshi Sugiura
- Atsushi Hozawa
- Mitsuhiro Yamada
Institutions
- Tohoku University (JP)
- Tohoku University Hospital (JP)
- Sendai Medical Center (JP)
- Tohoku Medical Megabank Organization (JP)
- Sendai City Hospital (JP)
Publication Details
- Journal
- Respiratory Investigation
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.resinv.2025.101343
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00