Anti-tumor effect of a histone deacetylase inhibitor on canine malignant melanoma
Canine malignant melanoma (CMM) is a highly aggressive tumor with limited treatment options. Histone deacetylase (HDAC) inhibitors have shown promise in cancer therapy by modulating gene expression. In this study, we investigated the anti-tumor effect of an HDAC inhibitor, vorinostat, on CMM cell lines. Vorinostat significantly suppressed cell proliferation through apoptosis and G0/G1 phase cell cycle arrest in vitro. These findings suggest that vorinostat might serve as a potential therapeutic agent for dogs with CMM, providing a basis for further in vivo studies.
Authors
- Yuko Hashimoto (ORCID: https://orcid.org/0009-0008-6641-6136)
- Namiko Ikeda (ORCID: https://orcid.org/0009-0008-9616-5753)
- Takaaki Iguchi (ORCID: https://orcid.org/0000-0001-9246-2349)
- Yosuke Takahashi (ORCID: https://orcid.org/0000-0003-2258-7204)
- Masahiro Shinada (ORCID: https://orcid.org/0000-0001-5639-8087)
- Takayuki Nakagawa (ORCID: https://orcid.org/0000-0002-3105-3864)
- Daiki Kato (ORCID: https://orcid.org/0000-0002-0964-4158)
- Yuka Kodera (ORCID: https://orcid.org/0009-0008-7383-7975)
- Miki Ando (ORCID: https://orcid.org/0000-0001-8871-1330)
- Toshio Li (ORCID: https://orcid.org/0009-0007-6425-106X)
- Ryohei Nishimura (ORCID: https://orcid.org/0000-0002-9528-5867)
- Tetsuya Kako (ORCID: https://orcid.org/0000-0002-1891-6346)
- Qin Shiyu
- Hayato SHIBAHARA
- Shoma KOSEKI
- Haruka MOTOI
Institutions
- Veterinary Medical Center (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of Veterinary Medical Science
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1292/jvms.25-0285
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science