<i>gem</i>-Difluorocyclopropane Synthesis by Copper-Catalyzed C(sp<sup>3</sup>)–H Addition of 1,3-Dioxolane to Difluorocyclopropenes
We report here a synthesis of gem-difluorocyclopropanes via a copper-catalyzed C(sp<sup>3</sup>)-H addition of dioxolane to difluorocyclopropenes. The combinational use of silane and dibenzoyl peroxide was crucial for promoting the reaction, enabling access to gem-difluorocyclopropanes with an acetal moiety in a cis configuration.
Authors
- Kazuhiro Morisaki (ORCID: https://orcid.org/0000-0002-5692-4726)
- Akira Murakami (ORCID: https://orcid.org/0000-0002-5694-2828)
- Yoshihiro Sato (ORCID: https://orcid.org/0000-0003-2540-5525)
Institutions
- Hokkaido University (JP)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1248/cpb.c25-00582
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hokkaido University
- Japan Society for the Promotion of Science