Germline DNA Repair and Immune-metabolic Alterations Suggest a Potentially Distinct Form of Early-onset Prostate Cancer in Men of African Descent
This study reveals a broader germline landscape in early-onset PCa among men of African descent. Inherited immune-metabolic dysfunction may contribute to tumorigenesis through microenvironmental dysregulation, highlighting novel pathways for investigation in larger and ancestrally diverse cohorts.
Authors
- Mickaelle Rose
- Mylène Annonay (ORCID: https://orcid.org/0000-0002-1639-8661)
- Alicia Martín Martínez (ORCID: https://orcid.org/0000-0002-4237-6378)
- Sylvie Merle
- Régine Marlin (ORCID: https://orcid.org/0000-0001-7580-2997)
- Émeline Colomba (ORCID: https://orcid.org/0000-0002-3631-316X)
- Alexis Vallard (ORCID: https://orcid.org/0000-0002-8147-1298)
- Jean-Samuel Loger
- Taïna Labeau
- Sabrina Pennont
- Odile Béra
- Sarah Malsa
- Sylviane Ulric-Gervaise
- Céline Minchaca
- Johan Rose-Dite-Modestine
Institutions
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Martinique (MQ)
Publication Details
- Journal
- European Urology Oncology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.euo.2025.11.015
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00