Novel decanoic acid derivatives and 3-farnesyl- <i>p</i> -hydroxybenzoic acid derivatives from the marine fungus <i>Aureobasidium pullulans</i> 8438

Eleven compounds were isolated from the secondary metabolites of the marine fungus <i>Aureobasidium pullulans</i> 8438, including three novel compounds, 9-hydroxy-massoia lactone (<b>1</b>), Ethyl p-hydroxybenzoate (3 <i>R</i>,5<i>R</i>)-3,5-dihydroxydecanoate (<b>2</b>), and (<i>R</i>)-9,10-dihydroxypropyl 4-hydroxy-5-((2<i>E</i>,6<i>E</i>)-3,7,11-trimethyldodeca-2,6,10-trien -1-yl) benzoate (<b>3</b>), along with 8 known compounds (<b>4</b>-<b>11</b>). Compounds <b>1</b>, <b>2</b> and <b>4-9</b> are decanoic acid derivatives, while both compounds <b>3</b> and <b>11</b> are 3-farnesyl-p-hydroxybenzoic acid derivatives. The planar structures of the new compounds were determined using high-resolution mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR) data. Their absolute configurations were established through the Snatzke method, quantum chemical calculations (including computational NMR and ECD), and DP4+ analysis. All isolated compounds were evaluated for their cytotoxic effects against human non-small cell lung cancer cells A549 and human cervical cancer cells HeLa.