Human umbilical cord-derived mesenchymal stem cells alleviate autoimmune hepatitis by inhibiting hepatic ferroptosis
Based on the above evidence, we propose that hUC-MSCs may ameliorate ConA-induced liver injury in mice, potentially through modulation of ferroptosis-related pathways, and we support further investigation of hUC-MSCs as potential treatments for AIH. We believe that further in-depth studies are still needed to elaborate on the detailed regulatory mechanisms of MSCs on the ferroptosis pathway during the treatment of AIH.
Authors
- Youhua Xu (ORCID: https://orcid.org/0000-0002-3258-013X)
- Weizhao Tong
- Ling Guo (ORCID: https://orcid.org/0000-0003-1118-6798)
- Yihua Chen (ORCID: https://orcid.org/0000-0003-1733-7980)
- Guoxin Hu (ORCID: https://orcid.org/0000-0001-5169-4696)
- Guangdong Tong (ORCID: https://orcid.org/0000-0002-8577-574X)
- Wei Zheng (ORCID: https://orcid.org/0000-0002-8942-1543)
- Xuanqiu He (ORCID: https://orcid.org/0000-0001-8248-0199)
- Bing Liu (ORCID: https://orcid.org/0000-0002-7313-6924)
- Li Zhang (ORCID: https://orcid.org/0000-0001-9216-0092)
- Yaqin Li (ORCID: https://orcid.org/0000-0002-5626-9557)
- Tao Zhou (ORCID: https://orcid.org/0000-0002-8339-6906)
Institutions
- Macau University of Science and Technology (MO)
- Guangzhou University of Chinese Medicine (CN)
- Peking University Shenzhen Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1371/journal.pone.0337060
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00