Comprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study
CAPTURE ALS is a scalable clinical research platform that connects scientists and patients to facilitate efficient translational research. The unique and deeply phenotyped data and biosamples are a global resource towards the development of biomarkers and understanding ALS biology. This study is registered at clinicaltrials.gov (NCT: NCT05204017).
Authors
- Yasser Iturria‐Medina (ORCID: https://orcid.org/0000-0002-9345-0347)
- Jason Karamchandani (ORCID: https://orcid.org/0000-0002-3906-5616)
- Peter Seres (ORCID: https://orcid.org/0000-0002-8812-2234)
- Simon J. Graham (ORCID: https://orcid.org/0000-0002-9647-6569)
- Alan C. Evans (ORCID: https://orcid.org/0000-0003-3841-6098)
- Ekaterina Rogaeva (ORCID: https://orcid.org/0000-0002-2852-0329)
- Fred Tam (ORCID: https://orcid.org/0000-0002-6509-6387)
- David Taylor (ORCID: https://orcid.org/0000-0002-2557-1710)
- HyungMo Kang (ORCID: https://orcid.org/0000-0002-7114-2159)
- Sanjay Kalra (ORCID: https://orcid.org/0000-0003-4762-8746)
- Wendy Johnston (ORCID: https://orcid.org/0000-0002-4330-5563)
- Jasna Križ (ORCID: https://orcid.org/0000-0002-1811-7456)
- Yana Yunusova (ORCID: https://orcid.org/0000-0002-2353-2275)
- Russell Greiner (ORCID: https://orcid.org/0000-0001-8327-934X)
- Angela Genge (ORCID: https://orcid.org/0000-0001-5587-9946)
- Shelagh K. Genuis (ORCID: https://orcid.org/0000-0002-4733-4011)
- Mathieu Blais (ORCID: https://orcid.org/0009-0001-9102-378X)
- Avnit Dhanoa
- Lorne Zinman (ORCID: https://orcid.org/0000-0002-8096-8366)
- Agessandro Abrahão (ORCID: https://orcid.org/0000-0003-1142-2842)
- Christine Vande Velde (ORCID: https://orcid.org/0000-0001-5926-1529)
- Kelvin E. Jones (ORCID: https://orcid.org/0000-0003-4764-7031)
- Marie‐Noëlle Boivin (ORCID: https://orcid.org/0009-0000-6073-9286)
- Liziane Bouvier (ORCID: https://orcid.org/0000-0002-7239-7639)
- Gerald Pfeffer (ORCID: https://orcid.org/0000-0002-7657-7098)
- Robert Bowser (ORCID: https://orcid.org/0000-0001-5404-7259)
- Samir Das (ORCID: https://orcid.org/0000-0003-2018-8760)
- Tanushka Anand (ORCID: https://orcid.org/0000-0003-2575-1663)
- Rida Abou-Haidar
- Westerly Luth
- Janice Robertson (ORCID: https://orcid.org/0009-0003-6467-4223)
- Nicolas Dupré (ORCID: https://orcid.org/0000-0001-7270-6115)
- Claire Magnussen (ORCID: https://orcid.org/0000-0003-3656-1195)
- Natalie Saunders (ORCID: https://orcid.org/0009-0008-5641-2940)
- Tania Bubela (ORCID: https://orcid.org/0000-0002-0807-2899)
- Clémence Tremblay-Desbiens
- Nicolas Ferry (ORCID: https://orcid.org/0009-0008-4732-0956)
- Geneviève Matte
- Yvonne Frater
- Julia Chiappini
- Harpreet Bhinder
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- Barrow Neurological Institute (US)
- University of Alberta (CA)
- University of Calgary (CA)
- Simon Fraser University (CA)
- University of Toronto (CA)
- Multiple Sclerosis Society of Canada (CA)
- Health Sciences Centre (CA)
- Alzheimer Society of Canada (CA)
- Occupational Cancer Research Centre (CA)
- Université Laval (CA)
- Hotchkiss Brain Institute (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1371/journal.pone.0332430
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00