Determination of appropriate time for establishing a model of postmenopausal osteoporosis induced by bilateral oophorectomy: From bibliometric analysis to animal experiment
This study demonstrates that, at 8 weeks of age, C57BL/6J mice are the most suitable animal model for bilateral ovariectomy, owing to their stable maturity. A postmenopausal osteoporosis model can be established 9 weeks after the initial operation, which can facilitate further research on postmenopausal osteoporosis.
Authors
- Xian Tang (ORCID: https://orcid.org/0009-0006-7139-9444)
- Kun Ai (ORCID: https://orcid.org/0000-0002-0439-0144)
- Linyu Yin
- Yujing Zhou
- Shanxi Wang
- Dandan Zhou (ORCID: https://orcid.org/0000-0002-4005-3225)
- Songtao Liu (ORCID: https://orcid.org/0000-0003-3114-7163)
- Yongqin Kuang (ORCID: https://orcid.org/0000-0003-4713-5378)
- Yan She (ORCID: https://orcid.org/0009-0007-4856-7881)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Xiangnan University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1371/journal.pone.0336703
- Citations
- 1
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 1.72