TNF-α and IFN-γ differentially regulate AML cell susceptibility to CD70-antibody-mediated cytotoxicity
CD70 is a promising target for NK cell-based immunotherapy in AML. However, IFN-γ-dependent upregulation of HLA molecules on AML cells contributes to resistance to ADCC. These findings underscore the need for rationale combination strategies in clinical trials to overcome this inducible immune escape mechanism.
Authors
- Marion Subklewe (ORCID: https://orcid.org/0000-0001-9154-9469)
- Ignazio Piseddu (ORCID: https://orcid.org/0000-0001-8331-9778)
- Hartmann Harz (ORCID: https://orcid.org/0000-0003-1218-2107)
- Martina Rudelius (ORCID: https://orcid.org/0000-0002-7332-4589)
- Veit Hornung (ORCID: https://orcid.org/0000-0002-4150-194X)
- Monika Sponheimer (ORCID: https://orcid.org/0009-0005-2568-3893)
- Andreas Maiser (ORCID: https://orcid.org/0000-0002-2349-5822)
- Sherif Abdelhamed (ORCID: https://orcid.org/0000-0002-3319-2403)
- Michelle Ulrich (ORCID: https://orcid.org/0009-0004-3010-8212)
- Anetta Marcinek
- Christian Wichmann (ORCID: https://orcid.org/0000-0001-5341-8804)
- Daniel Diolaiti (ORCID: https://orcid.org/0000-0002-3839-8814)
- Daniel Richter (ORCID: https://orcid.org/0000-0001-6947-8350)
- Heinrich Leonhardt (ORCID: https://orcid.org/0000-0002-5086-6449)
- Daniel Nixdorf (ORCID: https://orcid.org/0000-0003-1612-9952)
- Nora Philipp (ORCID: https://orcid.org/0000-0002-3918-7795)
- Andreas Linder (ORCID: https://orcid.org/0000-0002-0623-5105)
- Veit Bücklein (ORCID: https://orcid.org/0000-0001-7391-7280)
- Lisa Rohrbacher (ORCID: https://orcid.org/0000-0001-7012-2896)
- Gerulf Hänel (ORCID: https://orcid.org/0000-0003-4685-6499)
- Maryam Kazerani (ORCID: https://orcid.org/0000-0002-5803-4807)
- Tobias Straub (ORCID: https://orcid.org/0000-0002-0547-0453)
- Kieron White (ORCID: https://orcid.org/0000-0001-6954-1831)
- Catharina Van Elssen (ORCID: https://orcid.org/0000-0003-1784-1765)
- Denis Maenner
- Eva Briem (ORCID: https://orcid.org/0009-0003-7506-3882)
- Niklas Kühl (ORCID: https://orcid.org/0000-0003-4970-4677)
- Giulia Rappa
- Emil Thore Tyborski
Institutions
- Pfizer (United States) (US)
- Maastricht University Medical Centre (NL)
- LMU Klinikum (DE)
- Maastricht University (NL)
- BioSystem (Germany) (DE)
- Bernstein Center for Computational Neuroscience Munich (DE)
- Cell Medica (Switzerland) (CH)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/jitc-2025-013024
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ludwig-Maximilians-Universität München