rs10204525 binding to miR-4717-3p modulates PD-1 expression and predicts the development of immune-related adverse events in patients with advanced cancer treated with anti-PD-1/PD-L1 therapy
These findings have high clinical relevance since they define rs10204525 binding to miR-4717-3p-mediated PD-1 expression and induction as a mechanism modulating the reactivity of immune cells to non-cancer cells as well as a novel biomarker for predicting irAEs in patients with advanced cancer treated with anti-PD-1/PD-L1-based immunotherapy.
Authors
- Emanuela De Bellis (ORCID: https://orcid.org/0000-0002-8543-5462)
- Francesco Sabbatino (ORCID: https://orcid.org/0000-0001-6431-8278)
- Giovanna Polcaro (ORCID: https://orcid.org/0000-0002-2329-3200)
- Valeria Conti (ORCID: https://orcid.org/0000-0001-6964-2739)
- Maddalena Langella (ORCID: https://orcid.org/0009-0008-0899-7219)
- Luigi Liguori (ORCID: https://orcid.org/0000-0002-0232-1452)
- Marco Cascella (ORCID: https://orcid.org/0000-0002-5236-3132)
- Berenice Stefanelli (ORCID: https://orcid.org/0000-0002-7986-8704)
- Valentina Manzo
- Cristina R. Ferrone (ORCID: https://orcid.org/0000-0002-6295-1085)
- Stefano Pepe (ORCID: https://orcid.org/0000-0003-0057-8411)
- Alessandro Ottaiano (ORCID: https://orcid.org/0000-0002-2901-3855)
- Alessandro Caputo (ORCID: https://orcid.org/0000-0001-5139-3869)
- Amelia Filippelli (ORCID: https://orcid.org/0000-0002-8235-9118)
- Valentina Pagliara (ORCID: https://orcid.org/0000-0001-9320-6080)
- Rosanna Martinelli (ORCID: https://orcid.org/0000-0002-6524-6752)
Institutions
- Cedars-Sinai Medical Center (US)
- University of Salerno (IT)
- Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/jitc-2025-012207
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00