Autophagy regulates MK-2206-induced LDL receptor expression and cholesterol efflux pathways
Both pharmacological and genetic impairment of autophagy attenuate the LDLR-inducing effects of MK-2206, supporting a role for autophagy in the regulation of cholesterol metabolism. The substantial reduction of ABCA1 expression in autophagy-deficient cells further indicates that autophagy is involved in cholesterol efflux regulation.
Authors
- Thea Bismo Strøm (ORCID: https://orcid.org/0000-0002-6636-9834)
- Hilde Sundvold (ORCID: https://orcid.org/0000-0003-0102-3362)
Institutions
- Oslo University Hospital (NO)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1371/journal.pone.0338076
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00