Front Cover: Lewis Acid‐Initiated Cleavage of a Large Ionophore: Molecular Deactivation by Potassium Ion Binding (ChemMedChem 23/2025)
Imagine a divalent metal ion (such as Zn(II)) binding to a folded ionophore such as salinomycin. The resulting complex is superacidified, shooting a proton at an unbound salinomycin molecule and cleaving it into two parts. However, when potassium ion is prebound to salinomycin, no superacidic protons are generated by this complex, whereas the protons generated by the divalent metal ion complex just bounce off. More details can be found in the Research Article by Adam Huczyński, Travis Dudding, Thomas Lectka, and co-workers (DOI: 10.1002/cmdc.202500783).
Authors
- Gareth E. Arnott (ORCID: https://orcid.org/0000-0002-6872-123X)
- Adam Huczyński (ORCID: https://orcid.org/0000-0003-4770-215X)
- Anand Vardhan (ORCID: https://orcid.org/0000-0001-7700-2336)
- Thomas Lectka (ORCID: https://orcid.org/0000-0003-3088-6714)
- Travis C. Dudding (ORCID: https://orcid.org/0000-0002-2239-0818)
- Jonah Ruskin (ORCID: https://orcid.org/0009-0006-4422-8535)
- Antonin Knirsch
Institutions
- Johns Hopkins University (US)
- Brock University (CA)
- Stellenbosch University (ZA)
- Adam Mickiewicz University in Poznań (PL)
Publication Details
- Journal
- ChemMedChem
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/cmdc.70134
- Primary Topic
- Molecular Sensors and Ion Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00