Matrix stiffness influences drug resistance to gemcitabine analog and AZD 1775 combination in PDAC organoids
AZD 1775 enhances the efficacy of Gemcitabine-8C at non-toxic doses, demonstrating its potential for overcoming PDAC treatment resistance. The cell origin and tumor microenvironment plays a key role in modulating drug response, highlighting the need for microenvironment and individualized-targeted strategies.
Authors
- Edward Agyare (ORCID: https://orcid.org/0000-0002-6905-5136)
- Bo Han (ORCID: https://orcid.org/0000-0003-1458-4265)
- Saunjoo L. Yoon (ORCID: https://orcid.org/0000-0001-5669-8709)
- Jonathan Barajas (ORCID: https://orcid.org/0009-0009-6759-6834)
- Xueyou Zhu
- Zhi Yang (ORCID: https://orcid.org/0009-0003-1586-3001)
Institutions
- University of Southern California (US)
- University of Florida (US)
- Florida Agricultural and Mechanical University (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1371/journal.pone.0326550
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00