Comparison of imaging-based bone marrow dosimetry methodologies and their dose–effect relationships in [177Lu]Lu-PSMA-617 RLT including a novel method with active marrow localization
The RM AD estimates from the blood-based surrogate were not concordant with the other image-based calculations and did not correlate with changes in blood values. Including patient-specific tumor and marrow distribution information resulted in lower AD for patients with a high bone metastatic burden. These findings have implications for managing hematological toxicities in <sup>177</sup>Lu RLT, especially if dosimetry-guided treatment planning is considered.
Authors
- Johan Blakkisrud (ORCID: https://orcid.org/0000-0002-0046-7327)
- Ka Kit Wong (ORCID: https://orcid.org/0009-0006-0837-7816)
- S.J. Wilderman
- Yuni K. Dewaraja (ORCID: https://orcid.org/0000-0002-3920-6925)
- Avery Peterson (ORCID: https://orcid.org/0000-0001-6531-5431)
- Kirk A. Frey (ORCID: https://orcid.org/0000-0002-5907-494X)
Institutions
- Oslo University Hospital (NO)
- Wayne State University (US)
- University of Michigan (US)
- Michigan Medicine (US)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1186/s40658-025-00816-6
- Citations
- 1
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36