Aphasic status epilepticus complicating hyperosmolar hyperglycaemic state

Aphasic status epilepticus is a rare neurological complication of the hyperosmolar hyperglycaemic state, a severe metabolic emergency in diabetes mellitus. Symptoms include language disturbance without significantly impaired consciousness. The diagnosis is complex, and management of the aphasic status epilepticus involves metabolic correction and antiseizure medications. We describe a 66-year-old man with type 2 diabetes who presented with progressive speech decline and impaired coordination following a fall. EEG confirmed non-convulsive status epilepticus, and MR brain scan showed transient left temporal changes with later hippocampal atrophy. Initial treatment with insulin and levetiracetam led to significant recovery. This case underscores hyperosmolar hyperglycaemic states as a reversible cause of aphasic status epilepticus and highlights the varied neurological presentations of uncontrolled diabetes. We include a review of the literature to contextualise this under-recognised clinical entity.

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Publication Details

Journal
Practical Neurology
Published
2025-12-04
DOI
https://doi.org/10.1136/pn-2025-004936
Primary Topic
Neurological and metabolic disorders
Type
article
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article

Aphasic status epilepticus complicating hyperosmolar hyperglycaemic state

Omar K. Bukhari, Laila Alqahtani, Benjamin Whatley, Sarah Alqhtani
Practical Neurology
Neurological and metabolic disorders
article

Aphasic status epilepticus complicating hyperosmolar hyperglycaemic state

Omar K. Bukhari, Laila Alqahtani, Benjamin Whatley, Sarah Alqhtani
article en

Abstract

Aphasic status epilepticus is a rare neurological complication of the hyperosmolar hyperglycaemic state, a severe metabolic emergency in diabetes mellitus. Symptoms include language disturbance without significantly impaired consciousness. The diagnosis is complex, and management of the aphasic status epilepticus involves metabolic correction and antiseizure medications. We describe a 66-year-old man with type 2 diabetes who presented with progressive speech decline and impaired coordination following a fall. EEG confirmed non-convulsive status epilepticus, and MR brain scan showed transient left temporal changes with later hippocampal atrophy. Initial treatment with insulin and levetiracetam led to significant recovery. This case underscores hyperosmolar hyperglycaemic states as a reversible cause of aphasic status epilepticus and highlights the varied neurological presentations of uncontrolled diabetes. We include a review of the literature to contextualise this under-recognised clinical entity.

Practical Neurology
Dalhousie University (CA), King Saud bin Abdulaziz University for Health Sciences (SA), King Fahd Medical City (SA), King Abdullah International Medical Research Center (SA)
Openalex Percentile: Top 49%
Neurological and metabolic disorders
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Aphasic status epilepticus complicating hyperosmolar hyperglycaemic state — Omar K. Bukhari, Laila Alqahtani, et al. · Practical Neurology (2025) | TGRS Research Map | TGRS