Expanding the donor pool: Outcomes of liver transplantation using grafts with ≥50% macrosteatosis
Liver grafts with over 50% macrosteatosis are often deemed marginal, but organ shortages necessitate exploring their use. We conducted five transplants with deceased donor grafts containing 50%-90% macrosteatosis, ensuring donor age <55 years, CIT ≤6 hours, and recipient laboratory MELD score ≤30. Two patients required reoperations due to thrombotic complications (acute HAT and PVT), and hospital stay ranged from 6 to 26 days. All patients survived beyond one year with functioning grafts. These findings suggest the feasibility of using high-macrosteatosis grafts in intermediate- to low-laboratory-MELD recipients, albeit with potential thrombotic risks.
Authors
- Daniel G. Maluf (ORCID: https://orcid.org/0000-0002-5921-4834)
- Francis E. Nieves
- Kirti Shetty (ORCID: https://orcid.org/0000-0002-7725-6050)
- Josue Alvarez-Casas
- Srinivasan Muthukrishnan (ORCID: https://orcid.org/0009-0008-9348-5778)
- Shani Kamberi (ORCID: https://orcid.org/0000-0002-9476-4858)
- Massimo Arcerito (ORCID: https://orcid.org/0000-0001-6906-9856)
- Ruchin Patel
- Raphaël Meier (ORCID: https://orcid.org/0000-0001-9050-0436)
- Kasra Shirini (ORCID: https://orcid.org/0000-0003-4104-7633)
- Saad Malik
- Chandra Bhati (ORCID: https://orcid.org/0000-0002-4333-5551)
- Omar Alattar (ORCID: https://orcid.org/0000-0002-2249-123X)
Institutions
- University of Maryland, Baltimore (US)
Publication Details
- Journal
- Journal of Liver Transplantation
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1016/j.liver.2025.100311
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00