Innate immune cell function in statin-treated patients with severe hypercholesterolemia is comparable to normocholesterolemic individuals: A cross-sectional study
Previous studies reported hyperresponsive monocytes in treatment-naïve patients with LDL-c > 4.9 mmol/l. We now demonstrate that in an independent cohort of patients with LDL-c > 4.9 who are treated for 12 months with lipid-lowering drugs, the monocyte phenotype and function was similar to that of normocholesterolemic controls. In addition, neutrophils phenotype was similar, while the secretion of several granular proteins was lower in the patients.
Authors
- Siroon Bekkering (ORCID: https://orcid.org/0000-0003-1149-466X)
- Jeanine E. Roeters van Lennep (ORCID: https://orcid.org/0000-0001-6870-9962)
- Niels Peter Riksen (ORCID: https://orcid.org/0000-0001-9197-8124)
- Harsh Bahrar (ORCID: https://orcid.org/0000-0002-7686-4281)
- Liesbeth van Emst
- Nils Rother (ORCID: https://orcid.org/0000-0001-5129-3956)
- Kim Steward
- Mihai G. Netea
Institutions
- University of Bonn (DE)
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- Atherosclerosis Plus
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.athplu.2025.11.004
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00