Serum Metabolomics for Prognostic Stratification in Resected Advanced-Stage Oral Cavity Cancer
In this cohort study, a high MetaboScore was associated with local recurrence, regional recurrence, and distant metastasis, even after conventional staging was applied, in OCSCC. Its derivation from a cohort predominantly composed of male patients with betel quid exposure and advanced-stage disease warrants caution. Prospective validation in more diverse populations comprising different etiologies, disease stages, and demographic characteristics will be essential before broad clinical implementation.
Authors
- Chun‐Ta Liao
- Chien‐Yu Lin (ORCID: https://orcid.org/0000-0003-4630-8724)
- Chih‐Hua Yeh (ORCID: https://orcid.org/0000-0001-6988-8739)
- Shiang‐Fu Huang (ORCID: https://orcid.org/0000-0003-3582-9938)
- Eric Yi-Liang Shen (ORCID: https://orcid.org/0000-0003-2910-1393)
- Chung‐Jan Kang (ORCID: https://orcid.org/0000-0002-5333-9396)
- Li-Yu Lee
- Hung‐Ming Wang (ORCID: https://orcid.org/0000-0003-0066-829X)
- Nai‐Ming Cheng
- Chia‐Hsun Hsieh
- S.-H. Ng
- Tzu-Chen Yen
Institutions
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- JAMA Otolaryngology–Head & Neck Surgery
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1001/jamaoto.2025.4267
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00