Tafenoquine lactation pharmacokinetics: a pilot study
This pilot study demonstrated measurable tafenoquine in breastmilk, with very small amounts of drug passing to babies on any given day but overall estimated RIDs around the conventional 10% threshold for safety concerns. Further studies are needed to determine with greater certainty the excretion of tafenoquine in breastmilk and drug concentrations in infant blood to inform recommendations for breastfeeding women.
Authors
- Mary Ellen Gilder (ORCID: https://orcid.org/0000-0001-8811-8123)
- Warunee Hanpithakpong (ORCID: https://orcid.org/0000-0002-2856-8218)
- Podjanee Jittamala (ORCID: https://orcid.org/0000-0002-1020-2760)
- Germana Bancone (ORCID: https://orcid.org/0000-0003-4550-0431)
- Gornpan Gornsawun
- Thanaporn Wattanakul (ORCID: https://orcid.org/0000-0002-7570-4665)
- Cindy S. Chu (ORCID: https://orcid.org/0000-0001-9465-8214)
- Nicholas John White (ORCID: https://orcid.org/0000-0002-1897-1978)
- Joel Tärning (ORCID: https://orcid.org/0000-0003-4566-4030)
- Makoto Saito (ORCID: https://orcid.org/0000-0002-1667-9287)
- Rose McGready (ORCID: https://orcid.org/0000-0003-1621-3257)
- François Henry Nosten (ORCID: https://orcid.org/0000-0002-7951-0745)
- Laaongsri Niwetphongprai
- Wirawatn Tawantochai
- Eh Heet
Institutions
- Mahidol University (TH)
- Mahosot Hospital (LA)
- University of Oxford (GB)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LA)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1186/s12936-025-05685-z
- Primary Topic
- Breastfeeding Practices and Influences
- Type
- article
- Field-Weighted Citation Impact
- 0.00