Multicenter Interspecialty Consensus on Experimental Oncology Drug–Related Ocular Adverse Event Reporting
The new experimental oncology drug-related ocular AE grading scales developed by the consensus panel were developed to be more concise, containing photographs where applicable, and to provide clear drug dose modification recommendations compared with the previous CTCAE. Use of these ocular AE grading scales may allow for more objective and consistent incidence measurements of ocular AEs throughout clinical trials and postmarketing, potentially facilitating safe testing of novel agents that may cause eye toxicity.
Authors
- Jordyn Silverstein (ORCID: https://orcid.org/0000-0002-8573-7145)
- Laura A. Huppert (ORCID: https://orcid.org/0000-0002-8512-5608)
- Ivana K. Kim (ORCID: https://orcid.org/0000-0003-0310-6129)
- Paula Raffin Pohlmann (ORCID: https://orcid.org/0000-0001-7914-5162)
- Janice Lu (ORCID: https://orcid.org/0009-0006-8926-6367)
- Stella K. Kim
- Neel D. Pasricha (ORCID: https://orcid.org/0000-0002-2327-5221)
- A. Jo Chien (ORCID: https://orcid.org/0000-0003-2978-6249)
- Gerami D. Seitzman (ORCID: https://orcid.org/0000-0003-1791-5509)
- Winston Chamberlain (ORCID: https://orcid.org/0000-0003-0007-9428)
- Kathryn Colby (ORCID: https://orcid.org/0000-0001-9192-9998)
- Wiley Chambers
- Alexa Glencer (ORCID: https://orcid.org/0000-0002-3183-1056)
- Laura J. Esserman (ORCID: https://orcid.org/0000-0001-9202-4568)
- Jessica G. Shantha (ORCID: https://orcid.org/0000-0002-4449-8598)
- Matilda F. Chan (ORCID: https://orcid.org/0000-0001-8679-6932)
- Lucia Sobrin (ORCID: https://orcid.org/0000-0003-1575-0819)
- Ethan S. Lindgren
- Bennie H. Jeng
- Hope S. Rugo (ORCID: https://orcid.org/0000-0001-6710-4814)
- Dimitra Skondra (ORCID: https://orcid.org/0000-0003-3862-6159)
- Rongshan Yan
- Asim V. Farooq (ORCID: https://orcid.org/0000-0002-8199-2915)
- William M. Boyd
- Debra A. Goldstein
- Kuldev Singh
Institutions
- Northwestern University (US)
- Massachusetts Eye and Ear Infirmary (US)
- United States Food and Drug Administration (US)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- Penn Presbyterian Medical Center (US)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- George Washington University (US)
- San Francisco Foundation (US)
- University of Chicago Medical Center (US)
- Northwestern University (PH)
- Northwestern Medicine (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- New York University (US)
- Smith-Kettlewell Eye Research Institute (US)
- University of Pennsylvania (US)
- The University of Texas Health Science Center at Houston (US)
- Stanford University (US)
Publication Details
- Journal
- JAMA Ophthalmology
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1001/jamaophthalmol.2025.3159
- Citations
- 1
- Primary Topic
- Drug-Induced Ocular Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 1.71